Cardiovascular Equipment Technology and Rhythmology

Location

Campus Offenburg, room STB 1.30

Profile and objectives

The Cardiovascular Device Technology and Rhythmology Laboratory (Cardiolab) is available to students of medical technology and other interested parties for cardiovascular and electrophysiological laboratory tests, project work and final theses and researchers for research projects. The laboratory tests carried out in small groups complement the lectures and seminars on medical technology with extensive biomedical data of practical relevance. Research and Teaching Systems are available to students, staff, interested parties and researchers in the Laboratory for Cardiovascular Device Technology and Rhythmology.

Scientific head of laboratory

Prof. Dr.-Ing. med. habil. Matthias Heinke, Fachingenieur der Medizin

Laboratory assistant

Johannes Hörth, M. Sc.

Equipment

The Laboratory for Cardiovascular Technology and Rhythmology includes Cardiovascular, Biosignal and Electrophysiology Research and Teaching Systems in combination with heart model, cardiac rhythm simulator, computer modeling and simulation, pacemaker, cardioverter/defibrillator, cardiac resynchronization therapy (CRT) and hemodynamic and electrophysiological measuring stations with the following essential components

  • Cardio Vascular Lab, Hemodynamic Management and Monitoring
  • Boston Scientific Pacemaker/ICD/CRT, Zoom Programmer, Latitute Telemonitoring
  • Medtronic Pacemaker/ICD/CRT, 9790 Programmer, CareLink Telemonitoring
  • Biotronics Pacemaker/ICD, ICS3000 Programmer
  • MediConnect Pacemaker/ICD/CRT/CCM Database
  • BT12 Electrocardiography, VM300, OriginPro, RedLab, LabVIEW, Matlab
  • EG12000 EKG-Module – 12 Kanal Oberflächen-EKG-Monitoring
  • Digital storage oscilloscopes PCLab2000, HMO1024 4-channel oscilloscope
  • CST (Computer Simulation Technology AG) for cardiac modelling and simulation
  • Pace 50E Esophageal Casting Stimulator, TO Electrodes, Left Heart Electrocardiography
  • BioRadio Telemonitoring and Telemedicine, VivoSense evaluation software
  • CardioScreen 1000 4TECT with ear sensor, CardioScreen 2000 with blood pressure cuff
  • TensoScreen CNAP Monitor, continuous and discontinuous arterial pressure
  • EP-Tracer EP-Aufnahmesystem mit eingebautem Stimulator
  • InterSim®II – interaktiver Herzrhythmussimulator mit EKG-Interface-Box
  • Calibration & Adjustment Metlog ESTA II Safety Tester for STK of medical devices
  • EP Map System, EP Perfect Navigation, electrophysiological 3D Heart Mapping System
  • Zoll AED Pro externer Defibrillator, Lifepak 20e AED / manueller externer Defibrillator/Monitor
  • Fluke Biomedical Impulse 7000DP Defibrillator-/externer Herzschrittmachertester
  • Fluke Biomedical ProSim 4 Vitalzeichen und EKG-Simulator
  • BARD Lab DUO EP - Electrophysiological Monitoring System

Internships and Tutorials

In the Laboratory Digital Storage Oscilloscopes (MT2) technical and biomedical signals at the Offenburg heart model and pacemaker as well as implant-based clinical cardiac arrhythmias, e.g. atrial flutter with a 2 to 1 atrial chamber transition are analyzed.

In the laboratory Biosignal Analysis (MT6) experiments on the Biosignal Research and Teaching System for biosignal analysis in conventional and transesophageal electrocardiography, sinus rhythm, atrial flutter, atrial fibrillation, AV blocking, right ventricular stimulation, late ventricular potentials, His-bundle potentials, pacemaker stimulation, ischemic and non ischemic cardiomyopathy and heart rhythm simulations with the InerSim II rhythm Simulator are performed. 

In the Cardiovascular Research and Teaching System laboratory (MT7), tests on the Cardiovascular Research and Teaching System are used to determine stroke volume, thoracic fluid, cardiac output, left ventricular ejection time, stroke volume index, prejection time, cardiac index, velocity index, ejection time index, acceleration index, ejection time ratio, heather index, systolic time ratio, Systolic Time Ratio Index, O/C ratio, atrioventricular delay, interventricular delay, sinus node dysfunction, atrial fibrillation, left bundle branch block, cardiac resynchronization therapy, Boston CRT-D, Medtronic CRT-D and CRT-P.

In the Laboratory QS/QM in medical Technology (MT7) tests with the MediConnect pacemaker/ICD/CRT/CCM database for quality assurance and quality management in medical technology are offered. In particular the topics quality management system according to ISO 9001 and ISO 13485, medical device law, medical device operator ordinance, safety of active medical devices, IEC 60601, safety and metrological control of medical devices, Equipment instruction, initial instruction by the manufacturer, instruction of employees, medical device representative guidelines/guide lines, degrees of recommendation and evidence levels for evidence-based diagnostics, therapy and cardiac device therapy are discussed in the course.

In the Masterlabor Biosignalanalyse und Elektrophysiologie (MTM) experiments on the Electrophysiology Research and Teaching System for triggering, signal aging, tachogram, FFT for transthoracic and transesophageal biosignals, cardiac micro potentials, Boston CRT-D and ICD, AV-node conduction, atrial flutter, atrial fibrillation, Spline interpolation, fusion of electrocardiographic and impedance cardiographic biosignals, electromechanical latency, dilated cardiomyopathy, coronary heart disease, spectrotemporal mapping, 3D vector loop, vector ECG in heart failure and pacemaker stimulation as well as intracardiac electrophysiological investigations with the EP-Tracer EP system,..... are performed. 

Subject areas for final theses

  • Modelling and simulation of cardiac arrhythmias, pacemakers, EPU, ablation, CRT, CCM,... with the simulation software CST
  • Electrode development for ablation, stimulation and electrocardiography on the Schalk- cardiac rhythm model with the simulation software CST
  • Biosignal processing and biosignal analysis with e.g. LabVIEW, Origin, Bard Lab Duo, InterSim II, PM/ICD, CRT, ECG, IKG, EPU in time domain, spectral domain, wavelet,...
  • Cardiovascular, electrocardiographic monitoring with e.g. EP-Tracer, Bard Lab Duo, CardioScreen, Bioradio, EG12000,...
  • Rhythmological quality assurance with Mediconnect, InterSim II, pacemaker, ICD, CRT, CCM, STK,...
  • Single and multi-channel stimulation with LabVIEW, NI MyRIO, ...
  • ablation and navigation with EPMap System
  • Further development of previous laboratory tests, design of new laboratory tests

News

https://ei.hs-offenburg.de/fakultaet/aktuelles/news-detail/article/offenburger-medizintechnikbeitrag-auf-dgk-kongress/

https://ei.hs-offenburg.de/fakultaet/aktuelles/news-detail/article/herzrhythmussimulation-auf-ehra-kongress/

http://www.schattenblick.info/infopool/medizin/krankhei/m4he1029.html

Campus-1-2018_Heinke.pdf

https://www.degruyter.com/view/j/cdbme.2018.4.issue-1/cdbme-2018-0105/cdbme-2018-0105.xml?format=INT

https://www.degruyter.com/view/j/cdbme.2018.4.issue-1/cdbme-2018-1131/cdbme-2018-1131.xml?format=INT

https://www.degruyter.com/view/j/cdbme.2018.4.issue-1/cdbme-2018-0113/cdbme-2018-0113.xml?format=INT

ei.hs-offenburg.de/fakultaet/aktuelles/news-detail/article/biomedical-technology-conference/

Fif-Magazin Beiträge Heinke

https://ei.hs-offenburg.de/fakultaet/aktuelles/news-detail/article/herzrhythmusstoerungen-besser-erkennen/

§https://www.hs-offenburg.de/aktuell/pressemitteilungen/detailansicht/article/herausragende-medizintechnikforschung/

https://www.inventionstore.de/angebot/4539/

https://medizin-aspekte.de/99225-wirkt-die-biomechanische-stimulation/

 http://article.scholarena.co/Simulation-of-Electrical-Fields-in-Cardiac-Resynchronization-Therapy-and-Temperature-Spread-in-HF-Ablation.pdf

§ https://ei.hs-offenburg.de/fakultaet/aktuelles/news-detail/article/offenburger-haemodynamik-und-biosignale-auf-der-bmtmedphys-2017/

§ https://ei.hs-offenburg.de/fakultaet/aktuelles/news-detail/article/herzrhythmustechnik-zum-anfassen/

§  http://iaf.hs-offenburg.de/fileadmin/Einrichtungen/iaf/file/FBericht/fif2017.pdf

§  http://ei.hs-offenburg.de/fakultaet/aktuelles/news-detail/article/resynchronisationsmodell-des-herzens-auf-internationalem-kongress/

§  http://www.hs-offenburg.de/aktuell/pressemitteilungen/detailansicht/article/medizintechnik-absolvent-praesentiert-ergebnisse-auf-tagung/

Publications

2018

M. Heinke, G. Dannberg, T. Heinke, H. Kühnert: Electrical Right and Left Cardiac Atrioventricular and Left Atrial Delay in Cardiac Resynchronization Therapy Responder and Non-responder with Sinus Rhythm. L. Lhotska et al. (eds.), World Congress on Medical Physics and Biomedical Engineering 2018 pp. 139-142, IFMBE Proceedings 68/2. Springer, Singapore, doi.org/10.1007/978-981-10-9038-7_25

J. Tumampos, M. Heinke: Spectral Analysis of Signal Averaging Electrocardiography in Atrial and Ventricular Tachycardia Arrhythmias. L. Lhotska et al. (eds.), World Congress on Medical Physics and Biomedical Engineering 2018 pp. 143-147, IFMBE Proceedings 68/2. Springer, Singapore doi.org/10.1007/978-981-10-9038-7_26

M. Heinke, G. Dannberg, T. Heinke, H. Kühnert: Electrical Right and Left Cardiac Atrioventricular and Left Atrial in Cardiac Resynchronization Therapy Responder and Non-responder with Sinus Rhythm. World Congress on Medical Physics & Biomedical Engineering, June 3–8, 2018 Prague, Czech Republic, IUPESM Book of Abstracts, P 535

J. Tumampos, M. Heinke: Spectral Analysis of Signal Averaging Electrocardiography in Atrial and Ventricular Tachycardia Arrhythmias. World Congress on Medical Physics & Biomedical Engineering, June 3–8, 2018 Prague, Czech Republic, IUPESM Book of Abstracts, P 503

K. Ehret, M. Heinke, J. Hörth: Electrode Model and Simulation of Catheter Ablation of Supraventricular Tachycardia. Acta Scientific Medical Sciences 2.9 (2018): 19-22. DOI:https://actascientific.com/ASMS/pdf/ASMS-02-0143.pdf,https://opus.hs-offenburg.de/frontdoor/index/index/docId/2979

T. Roller, M. Heinke, J. Hörth: Pacing electrode modeling and simulation of cardiac contractility modulation. Current Directions in Biomedical Engineering 2018; 4(1): 551 – 554, DOI: doi.org/10.1515/cdbme-2018-1131, www.degruyter.com/downloadpdf/j/cdbme.2018.4.issue-1/cdbme-2018-1131/cdbme-2018-1131.pdf, opus.hs-offenburg.de/frontdoor/index/index/docId/2970

K. Göküs, M. Heinke, J. Hörth: Heart rhythm model for the simulation of electric fields in trans esophageal atrial pacing and cardiac resynchronization therapy. Current Directions in Biomedical Engineering 2018; 4(1): 443 – 445, DOI: doi.org/10.1515/cdbme-2018-0105, www.degruyter.com/downloadpdf/j/cdbme.2018.4.issue-1/cdbme-2018-0105/cdbme-2018-0105.pdf, opus.hs-offenburg.de/frontdoor/index/index/docId/2971

R. Müssig, M. Heinke, J. Hörth: Cryoballoon model and simulation of catheter ablation for pulmonary vein isolation in atrial fibrillation. Current Directions in Biomedical Engineering 2018; 4(1): 473 – 475, DOI: doi.org/10.1515/cdbme-2018-0113, www.degruyter.com/downloadpdf/j/cdbme.2018.4.issue-1/cdbme-2018-0113/cdbme-2018-0113.pdf, opus.hs-offenburg.de/frontdoor/index/index/docId/2969

M. Krämer, M. Heinke: Herzrhythmusmodell zur Simulation elektrischer und thermischer Felder bei kardialer Resynchronisationstherapie und Hochfrequenz Ablation. Clin Res Cardiol 107, Suppl 1, April 2018, Beitrag P442, DOI: doi.org/10.1007/s00392-018-1216-4, www.abstractserver.com/dgk2018/jt/abstracts/P442.HTM

M. Krämer, M. Heinke, J. Hörth: Electrical field simulations in cardiac resynchronization therapy and ablation. The Sixth International Conference on Biotechnology and Bioengineering (ICBB2017) 26–28 September 2017, Offenburg, Germany, Basic Clin Pharmacol Toxicol 2018; 122, S-P29, doi:10.1111/bcpt.12952, doi.org/10.1111/bcpt.12952

M. Schalk, M. Heinke, J. Hörth: Heart rhythm model for simulation in electrophysiological studies and ablation The Sixth International Conference on Biotechnology and Bioengineering (ICBB2017) 26–28 September 2017, Offenburg, Germany, Basic Clin Pharmacol Toxicol 2018; 122, doi:10.1111/bcpt.12952, doi.org/10.1111/bcpt.12952

E. Benke, M. Heinke, J. Hörth: 3D-Simulation elektrischer Stimulationsfelder bei Herzschrittmachern. Forschung im Fokus 2018, Institut für Angewandte Forschung Hochschule Offenburg, Ausgabe Nr. 21, 2018, 21 – 22

J. Tumampos, M. Heinke, J. Hörth: Signalgemittelte Elektrokardiographie und spektrale Herzrhythmusanalyse. Forschung im Fokus 2018, Institut für Angewandte Forschung Hochschule Offenburg, Ausgabe Nr. 21, 2018, 23 – 24

2017

M. Krämer, M. Heinke, R. Echle, J. Hörth: Simulation of Electrical Fields in Cardiac Resynchronization Therapy and Temperature Spread in HF Ablation, Scholarena - SAJ Biotechnology 4:102, ISSN: 2375-6713, December 2017

M. Heinke, M. Schalk: Ösophaguselektrodensonden und Vorrichtung zur kardiologischen Behandlung und/oder Diagnose. Deutsches Patent- und Markenamt (DPMA), Deutsche Patentanmeldung Anmeldetag 7.11.2017

M. Heinke, G. Dannberg, T. Heinke, J. Hörth, H. Kühnert: Electrical interventricular delay and left ventricular delay in right ventricular pacemaker pacing before upgrading to cardiac resynchronization therapy. Current Directions in Biomedical Engineering 2017; 3(2): 245-248

M. Krämer, M. Heinke, J. Hörth: Electrical field simulations in cardiac resynchronization therapy and ablation. ICBB 2017 & 6th ICBB, 6th International Conference on Biotechnology and Bioengineering 2017 International Conference on Advances in Biomedicine and Biomedical Engineering, September 26th-28th, Offenburg Germany. Abstract Book, S-P29

M. Schalk, M. Heinke, J. Hörth: Heart rhythm model for Simulation in electrophysiological studies and ablation. ICBB 2017 & 6th ICBB, 6th International Conference on Biotechnology and Bioengineering 2017 Intenational Conference on Advances in Biomedicine and Biomedical Engineering, September 26th-28th, Offenburg Germany, Abstract-Book

M. Krämer, M. Heinke, R. Echle, J. Hörth: Simulation of electrical fields in cardiac resynchronization therapy and temperature spread in HF ablation. Abstracts - BMTMedPhys 2017 - Dresden, September m 10-13 • DOI 10.1515/bmt-2017-5032, Biomed. Eng.-Biomed. Tech. 2017; 62(s1): P 107, S155

J. Tumampos, M. Heinke, J. Hörth: Spectral Analysis of Signal averaging electrocardiography in atrial and ventricular tachyarrhythmias. Abstracts - BMTMedPhys 2017 - Dresden, September 10-13 • DOI 10.1515/bmt-2017-5032, Biomed. Eng-Biomed.Tech. 2017; 62(sl): P 257, S366

M. Schalk, M. Heinke, J. Hörth: Heart rhythm model and Simulation of electrophysiological studies and high-frequency ablations. Abstracts - BMTMedPhys 2017 - Dresden, September 10-13 • DOI 10.1515/bmt-2017-5032, Biomed. Eng.-Biomed. Tech. 2017; 62(sl): P 289, S394

M. Krämer, R. Echle, L. Schüssele, M. Heinke: E-Feld-Simulation bei CRT und Ablation. Forschung im Fokus 2017, Institut für Angewandte Forschung Hochschule Offenburg, Ausgabe Nr. 20, 2017, 61-65

M. Schalk, R. Echle, L. Schüssele, M. Heinke: Herzrhythmusmodell zur Simulation von EPU und Ablation. Forschung im Fokus 2017, Institut für Angewandte Forschung Hochschule Offenburg, Ausgabe Nr. 20, 2017 62-63

M. Heinke, G. Dannberg, H. Kühnert: Interventricular delay and left ventricular delay in right ventricular Pacemaker pacing before upgrading to beventricular pacing. Europace 19, Suppl. 3, 2017, iii314

M. Kraemer, R. Echle, M. Heinke: Simulation of electrical fields in cardiac resynchronization therapy and temperature spread in HF ablation. Europace 19, Suppl. 3, 2017, iii185

M. Schalk, M. Heinke, R. Echle: Heart rhythm model and Simulation of electrophysiological studies and high-frequency ablations. Europace 19, Suppl. 3, 2017, iii182

M.Heinke, H. Kühnert, G. Dannberg: Elektrisches interventrikuläres und linksventrikuläres Delay bei rechtsventrikulärer Stimulation vor Aufrüstung auf biventrikuläre Stimulation. Clin Res Cardiol 106, Suppl 1, April 2017, P1836

M. Schalk, M. Heinke, R. Echle: Heart rhythm model and simulation of electrophysiological studies and high-frequency ablations. Clin Res Cardiol 106, Suppl 1, April 2017, P1812

2016

M. Heinke, H. Kühnert, T. Heinke, J. Tumampos, G. Dannberg: Left cardiac atrioventricular delay and inter-ventricular delay in cardiac resynchronization therapy responder and nonresponder. Current Directions in Biomedical Engineering; 2016; 2(1): 247-250, DOI 10.1515/cdbme-2016-0055

M. Heinke, H. Kühnert, G. Dannberg: Electrical interventricular delay to left ventricular delay ratio in atrial fibrillation cardiac resynchronization therapy responder and non-responder. Europace 18, Suppl.1, June 2016, 19-01, i164

M. Heinke, H. Kühnert, G. Dannberg: Intrakardiales und transösophageales elektrisches interventrikuläres Delay Verhältnis bei kardialer Resynchronisationstherapie. Clin Res Cardiol 105, Suppl 1, March 2016, V1218, DOI 10.1007/s00392-016-0967-z.

M. Heinke, G. Dannberg, H. Kühnert: Kardiale Desynchronisation bei Resynchronisationstherapie. Forschung im Fokus 2016, Institut für Angewandte Forschung Hochschule Offenburg, Ausgabe Nr. 19, 2016, 12 – 14

P. Hoch, J. Tumampos, M. Heinke: Rhythmologisches Qualitätsmanagement mit MediConnect® & Latitude™ . Forschung im Fokus 2016, Institut für Angewandte Forschung Hochschule Offenburg, Ausgabe Nr. 19, 2016, 12 – 14

P. C. Takam, J. Tumampos, M. Gick, R. Kienzle, M. Heinke: Pacemaker and electrocardiography measurements in TAVI. Current Directions in Biomedical Engineering; 2016; 61 (s60), DOI 10.1515/bmt-2016-5005

N. Schuler, M. Heinke, J. Tumampos: Transthoracic impedance cardiography measurements with different monitoring devices. Current Directions in Biomedical Engineering; 2016; 61 (s65), DOI 10.1515/bmt-2016-5005